Steve Ealick's Research Group

Jarrod B. French

Email: jbf37@cornell.edu

BSc: Chemistry and Biology double major; Brock University, Ontario, Canada

MSc: Biomedical Science, Weill Medical School, Cornell University with Dr. Anthony Sauve

Project: Understanding Nicotinamidases and Their Potential as Antimicrobial Drug Targets

Experience:

Sixth Year Graduate Student
Tri-Institutional Training Program in Chemical Biology (TPCB)

Current Projects:

Structural and mechanistic studies of the nicotinamidase enzyme.
Structure of Thi20, a fusion protein containing domains homologous to ThiD and TenA
Structure of Leishmania donovanii Orotidine 5'-Monophosphate Decarboxylase - Orotate Phosphoribosyltransferase (OMPDC-OPRT)

Publications:

French, J. B., Holland, G., Holland, H. L., and Gordon, H. L. (2004) A comparative molecular field analysis of the biotransformation of sulfides by Rhodococcus erythropolis, J. Mol. Catal. B: Enzym. 31, 87-96.

Holland, H. L., Brown, F. M., Barrett, F., French, J., and Johnson, D. V. (2003) Biotransformation of β-ketosulfides to produce chiral b-hydroxysulfoxides, J. Indust. Microbiol. Biotech. 30, 292-301.

French, J.B., Cen, Y., Sauve, A.A. Plasmodium falciparum Sir2 is an NAD⁺-Dependent Deacetylase and an Acetyllysine-Dependent and Acetyllysine-Independent NAD⁺ Glycohydrolase. Biochemistry (2008) in press. PubMed