Chemistry 7880/BioBM 7380
Macromolecular Crystallography
Spring 2010
 |
Professor Steve Ealick
TTh 1:25 PM - 2:40 PM, Baker 335 3 credits Prerequisites:
Textbook: Bernhard Rupp, Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology; ISBN 9780815340812 Class Syllabus and Lecture Notes |
Knowledge of protein structure is becoming increasingly essential for, among other tasks, helping to elucidate reaction mechanisms, determining prospective targets for drug interaction, and exploring the evolution of protein function. In this course, Steve Ealick will guide you through the fundamentals of protein crystallography, focusing on methods for determining the 3-dimensional structures of macromolecules.
Topics will include:
protein crystallization, data collection, multiple isomorphous replacement, molecular replacement, model building, refinement, and structure interpretation.
